Whenever you may received following error while installing package or update in your CentOS or Fedora
 
"[Errno 14] PYCURL ERROR 22 - "The requested URL returned error: 404 Not Found"

#  yum install lsof -y


Loaded plugins: fastestmirror

Loading mirror speeds from cached hostfile

 * base: centos-hn.viettelidc.com.vn

 * epel: epel.mirror.srv.co.ge

 * extras: centos.aol.in

 * updates: centos-hcm.viettelidc.com.vn

http://centos-hn.viettelidc.com.vn/6.5/os/x86_64/repodata/repomd.xml: [Errno 14] PYCURL ERROR 22 - "The requested URL returned error: 404 Not Found"

Trying other mirror.

http://centos.aol.in/6.5/os/x86_64/repodata/repomd.xml: [Errno 14] PYCURL ERROR 22 - "The requested URL returned error: 404 Not Found"

Trying other mirror.

http://centos.mirror.net.in/centos/6.5/os/x86_64/repodata/repomd.xml: [Errno 14] PYCURL ERROR 7 - "couldn't connect to host"

Trying other mirror.

http://centosmirror.go4hosting.in/centos/6.5/os/x86_64/repodata/repomd.xml: [Errno 14] PYCURL ERROR 22 - "The requested URL returned error: 404 Not Found"

Open repo configure file "epel.repo" and change following two lines,
 
Use the baseurl instead of the mirrorlist for downloading package from source, just command the mirrorlist line and get from baseurl
 
# vim /etc/yum.repos.d/epel.repo


#baseurl=http://download.fedoraproject.org/pub/epel/6/$basearch

mirrorlist=https://mirrors.fedoraproject.org/metalink?repo=epel-6&arch=$basearch

Change to


baseurl=http://download.fedoraproject.org/pub/epel/6/$basearch

#mirrorlist=https://mirrors.fedoraproject.org/metalink?repo=epel-6&arch=$basearch

Final output:


[epel]

name=Extra Packages for Enterprise Linux 6 - $basearch

baseurl=http://download.fedoraproject.org/pub/epel/6/$basearch

#mirrorlist=https://mirrors.fedoraproject.org/metalink?repo=epel-6&arch=$basearch

failovermethod=priority

enabled=1

gpgcheck=1

gpgkey=file:///etc/pki/rpm-gpg/RPM-GPG-KEY-EPEL-6